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利多卡因用于小型外科手术术后的高铁血红蛋白血症发病率。

Methemoglobinemia incidence after the application of lidocaine for small surgical procedures.

作者信息

Günal Elnare, Akkuş Yeliz, Çığşar Gülşen, Çiftçi Handan, Kahramanca Şahin, Özdemir Murat

机构信息

Department of Nursing, Kafkas University Faculty of Health Sciences, Kars, Turkey.

出版信息

Agri. 2017 Oct;29(4):173-176. doi: 10.5505/agri.2017.91328.

Abstract

OBJECTIVES

Methemoglobinemia (MetHb) is a rare condition that may have mortal consequences. Literature shows cases of methemoglobinemia due to the use of lidocaine and other local anesthetics. This is a cross-sectional study to determine the incidence of methemoglobinemia after the application of lidocaine.

METHODS

In this study, 88 patients admitted to the emergency department of a university hospital between May 2014 and May 2015 and needed lidocaine application for small surgical procedures were included. When compared before and after the administration of lidocaine <2 mg/kg and >2 mg/kg, there was not a significant difference in the level of methemoglobin, hemoglobin, or in the hematocrit (p=0.604, p=0.502, and p=0.367, respectively).

RESULTS

Mean age of the patients was 33.85 (±17.58) years, and 83% of the patients were male. Methemoglobin levels were not significantly different before and after the procedures (p>0.05).

CONCLUSION

The results of our study were consistent with the literature; lidocaine associated methemoglobinemia is a rare complication.

摘要

目的

高铁血红蛋白血症(MetHb)是一种可能导致致命后果的罕见病症。文献显示有因使用利多卡因和其他局部麻醉剂而引发高铁血红蛋白血症的病例。这是一项横断面研究,旨在确定应用利多卡因后高铁血红蛋白血症的发生率。

方法

本研究纳入了2014年5月至2015年5月间入住某大学医院急诊科且因小型外科手术需要应用利多卡因的88例患者。在给予小于2mg/kg和大于2mg/kg的利多卡因前后进行比较时,高铁血红蛋白水平、血红蛋白水平或血细胞比容均无显著差异(p值分别为0.604、0.502和0.367)。

结果

患者的平均年龄为33.85(±17.58)岁,83%的患者为男性。手术前后高铁血红蛋白水平无显著差异(p>0.05)。

结论

我们的研究结果与文献一致;利多卡因相关的高铁血红蛋白血症是一种罕见的并发症。

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