Szaliński M R, Turno-Krecicka A
Katedry i Zakładu Farmakologii AM we Wrocławiu.
Klin Oczna. 2001;103(4-6):203-5.
This paper presents the classification of prostaglandins and their receptors. The ocular distribution of the receptors and the effects of their agonists are presented. The efficacy in lowering intraocular pressure of different prostaglandins and their derivatives, especially the PGF2a group, is discussed. The history of latanoprost development is also presented. Good therapeutic index characterises two antiglaucomatous PG-derivatives: latanoprost and unoprostone.
本文介绍了前列腺素及其受体的分类。阐述了这些受体的眼部分布及其激动剂的作用。讨论了不同前列腺素及其衍生物，尤其是前列腺素F2α类，在降低眼压方面的疗效。还介绍了拉坦前列素的研发历程。两种抗青光眼的前列腺素衍生物——拉坦前列素和乌诺前列酮具有良好的治疗指数。
