哌甲酯对网状结构和丘脑神经元活动的不同影响。
Differential effects of methylphenidate on reticular formation and thalamic neuronal activity.
作者信息
Shih T M, Khachaturian Z S, Barry H, Reisler K L
出版信息
Psychopharmacologia. 1975 Oct 14;44(1):11-5. doi: 10.1007/BF00421176.
PMID:1197575
Abstract
Intravenous administration of methylphenidate (1 or 2 mg/kg) markedly attenuated the unit discharge rate in the mesencephalic reticular formation of rats and cats. Concurrently this drug enhanced the neural activity in the primary sensory nuclei of the thalamus. The differential effect of methylphenidate on these two neural systems suggest a possible mechanism by which it may improve attentive processes in hyperkinesis.
摘要
静脉注射哌醋甲酯（1或2毫克/千克）可显著降低大鼠和猫中脑网状结构的单位放电率。同时，这种药物增强了丘脑主要感觉核中的神经活动。哌醋甲酯对这两个神经系统的不同作用提示了一种可能的机制，通过该机制它可能改善多动症患者的注意力过程。
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