Pontzer N J, Wilkison D M
Exp Neurol. 1987 Sep;97(3):644-52. doi: 10.1016/0014-4886(87)90121-x.
The effects of delta-9-tetrahydrocannabinol on sensory activity in the thalamic intralaminar nuclei, centralis lateralis and the mesencephalic reticular formation were compared with the effects on cortical association or heterosensory systems in alpha-chloralose-anesthetized cats. The drug depressed the anterior marginal responses to multiple-modality sensory stimulation 30 min after administration of 2 mg/kg. Posterior suprasylvian responses were not significantly depressed except during 15 min postadministration. The drug did not depress sensory responses at the centralis lateralis or the mesencephalic reticular formation. Cortical responses evoked by stimulation of the latter were globally depressed by the drug. In contrast, delta-9-tetrahydrocannabinol depressed the anterior marginal response to centralis lateralis stimulation and not the posterior suprasylvian response similarly to the responses to sensory stimulation. The drug was without effect on caudate nucleus responses to stimulation of the mesencephalic reticular formation or centralis lateralis. These data demonstrate that, unlike pentobarbital, delta-9-tetrahydrocannabinol maintains heterosensory afferent activity to mesencephalic and thalamic sites and that its unique properties appear to be due, in part, to the selective disruption of heterosensory thalamocortical function.
在α-氯醛糖麻醉的猫中，将δ-9-四氢大麻酚对丘脑板内核、外侧中央核和中脑网状结构感觉活动的影响，与对皮质联合或异感觉系统的影响进行了比较。给予2mg/kg药物30分钟后，该药物抑制了对多模式感觉刺激的前缘反应。除给药后15分钟外，后薛氏回反应没有明显受到抑制。该药物没有抑制外侧中央核或中脑网状结构的感觉反应。刺激后者所诱发的皮质反应受到该药物的整体抑制。相比之下，δ-9-四氢大麻酚抑制了对外侧中央核刺激的前缘反应，而对后薛氏回反应的抑制与对感觉刺激的反应不同。该药物对尾状核对中脑网状结构或外侧中央核刺激的反应没有影响。这些数据表明，与戊巴比妥不同，δ-9-四氢大麻酚维持了向中脑和丘脑部位的异感觉传入活动，并且其独特性质似乎部分归因于异感觉丘脑皮质功能的选择性破坏。
