Naseer N, Aijaz A, Saleem M A, Nelson J, Peterson S J, Frishman W H
Divisions of General Internal Medicine, New York Medical College/Westchester Medical Center, Valhalla, New York 10595, USA.
Heart Dis. 2001 Jul-Aug;3(4):221-3. doi: 10.1097/00132580-200107000-00003.
Thrombotic thrombocytopenic purpura is a rare complication of ticlopidine treatment. This syndrome has been reported to occur typically within the first few weeks after the initiation of therapy. The authors describe a case of a 72-year-old woman in whom thrombotic thrombocytopenic purpura developed just 2 days after starting ticlopidine therapy for a new-onset ischemic stroke. The patient responded successfully to plasmapheresis. The authors are reporting this case to emphasize the unpredictable nature of the association between the drug and the disease, which necessitates careful hematologic monitoring.
血栓性血小板减少性紫癜是噻氯匹定治疗的一种罕见并发症。据报道，这种综合征通常在治疗开始后的头几周内出现。作者描述了一例72岁女性病例，该患者在开始使用噻氯匹定治疗新发缺血性中风仅2天后就发生了血栓性血小板减少性紫癜。患者接受血浆置换治疗后成功康复。作者报告此病例是为了强调药物与该疾病关联的不可预测性，这需要进行仔细的血液学监测。
