Türken Orhan, Oztürk Ahmet, Orhan Bülent, Kandemir Gökhan, Yaylaci Mustafa
Department of Hematology and Oncology, GATA Haydarpaşa Training Hospital, Istanbul, Turkey.
Acta Haematol. 2003;109(1):40-2. doi: 10.1159/000067270.
Thrombotic thrombocytopenic purpura is a syndrome characterized by hemolytic anemia, thrombocytopenia, neurological symptoms, fever and renal dysfunction. Although the syndrome is usually associated with various infections, vasculitis and pregnancy, rarely can it be associated with certain neoplasms and drugs such as ticlopidine. A 63-year-old woman, who had undergone coronary angioplasty and had been started on ticlopidine, was admitted to our clinic with a history of vomiting, fatigue, hematuria and deterioration in her cognitive abilities. Thrombotic thrombocytopenic purpura was diagnosed on the basis of neurological changes, an increase in LDH, urea, creatinine, indirect bilirubin levels, anemia and peripheral smear findings. Treatment was initiated with daily plasmapheresis and complete clinical and laboratory recovery developed. The patient was discharged after 14 days.
血栓性血小板减少性紫癜是一种以溶血性贫血、血小板减少、神经症状、发热和肾功能不全为特征的综合征。尽管该综合征通常与各种感染、血管炎和妊娠有关，但很少与某些肿瘤和药物（如噻氯匹定）有关。一名63岁的女性，曾接受冠状动脉血管成形术并开始服用噻氯匹定，因呕吐、疲劳、血尿和认知能力下降的病史入住我们的诊所。根据神经学变化、乳酸脱氢酶、尿素、肌酐、间接胆红素水平升高、贫血和外周血涂片检查结果诊断为血栓性血小板减少性紫癜。开始每日进行血浆置换治疗，患者临床和实验室检查结果完全恢复。14天后患者出院。
