Delacour H, Cléry C, Masson P, Vidal D R
Centre de Recherches du Service de Santé des Armées Emile Pardé , Département de Biologie des agents transmissibles, Unité de microbiologie, 24, avenue des maquis du Grésivaudan, F 38702 La Tronche.
Ann Pharm Fr. 2002 Jan;60(1):38-43.
High pressure biotechnology was developed in Japan in the 90's. This new technology has been used in several domains, including chemical synthesis, food industry, physical chemistry of proteins. Moreover, it could be used instead of heat or chemical treatment for inactivation of pathogenic micro-organisms. Hydrostatic pressures ranging from 100 to 300 MPa cause the inactivation of viruses, parasites, yeast and bacteria. However, bacterial spores are particularly resistant and their inactivation by high hydrostatic pressure can be achieved in combination with synergistic treatments (heat, chemicals and ultrasound).
高压生物技术于20世纪90年代在日本得到发展。这项新技术已应用于多个领域，包括化学合成、食品工业、蛋白质物理化学。此外，它可用于替代加热或化学处理来灭活致病微生物。100至300兆帕的静水压力可导致病毒、寄生虫、酵母和细菌失活。然而，细菌芽孢具有特别强的抗性，通过高静水压力使其失活可与协同处理（加热、化学物质和超声波）相结合来实现。
