Intiso D, Crociani P, Fogli D, Grandone E, Cappucci G, Di Rienzo F, Di Viesti P, Simone P, Tonali P
Department of Neurology, IRCCS Casa Sollievo della Sofferenza, Viale dei Cappuccini 1, I-71013 San Giovanni Rotondo (FG), Italy.
Neurol Sci. 2002 Mar;22(6):455-8. doi: 10.1007/s100720200005.
The occurrences of factor V Leiden mutation (Arg506Gln) and antiphospholipid antibodies (APA) in migraine patients have been reported, but the findings are controversial. We investigated the presence of factor V Leiden and the serum level of anticardiolipin antibodies (aCL) in a consecutive series of 70 migraine patients (47 women; mean age, 34.1 years). Of these, 40 patients had migraine with aura. A matched sample of 70 healthy people was considered as the control group. Heterozygous genotype for factor V Leiden mutation was detected in 4 (5.7%) migraine patients (of which 2 had migraine with aura) and in 2 (2.8%) subjects of the control group. Although proportionally more migraine patients harbored the factor V Leiden mutation, this difference was not statistically significant, perhaps due to the small number of patients involved. We found normal serum levels of aCL in all migraine patients. Further studies and a long-term follow-up are warranted to determine the significance of this genetic abnormality in migraine.
已有报道称偏头痛患者中存在因子V莱顿突变（Arg506Gln）和抗磷脂抗体（APA），但其研究结果存在争议。我们对连续的70例偏头痛患者（47例女性；平均年龄34.1岁）进行了研究，检测其因子V莱顿的存在情况及抗心磷脂抗体（aCL）的血清水平。其中，40例患者有先兆偏头痛。选取70例健康人作为匹配样本作为对照组。在4例（5.7%）偏头痛患者（其中2例有先兆偏头痛）及2例（2.8%）对照组受试者中检测到因子V莱顿突变的杂合基因型。虽然偏头痛患者中携带因子V莱顿突变的比例相对较高，但这种差异无统计学意义，可能是由于参与研究的患者数量较少。我们发现所有偏头痛患者的aCL血清水平均正常。有必要进行进一步研究和长期随访，以确定这种基因异常在偏头痛中的意义。
