Rymarz E, Mosiewicz J, Hanzlik J
1st Department of Internal Medicine, Medical University of Lublin.
Ann Univ Mariae Curie Sklodowska Med. 2001;56:1-6.
The aim of the paper was assessing the influence of polarizing GIK mixture on the selected indicators of acid-base equilibrium in patients with acute myocardial infarction treated fibrinolytically. The patients had arterial blood taken in order to check pH, partial pressure of oxygen and carbon dioxide, and the content of bicarbonates. Changes in the examined parameters in the group obtaining GIK and in the one obtaining placebo were subject to critical analysis. Changes in gasometric parameters taking place under the influence of GIK administered to patients were also analysed according to the site of infarction. It was observed that after 24 hours from the beginning of infusion pH increased and pCO2 decreased in comparison to the initial examination. These changes did not depend on the kind of applied infusion (GIK or physiological saline infusion), no significant changes in bicarbonates being observed. However, after applying GIK infusion, an increase in oxygen pressure in comparison with the control group was observed, and differences between the groups were within the boundaries of significance. Neither was there observed any influence of infarction site on changes in the assessed parameters of acid-base equilibrium in the group treated with GIK nor in the one receiving placebo.
本文旨在评估极化液（GIK）对接受溶栓治疗的急性心肌梗死患者酸碱平衡相关指标的影响。患者采集动脉血以检测pH值、氧分压和二氧化碳分压以及碳酸氢盐含量。对接受GIK治疗组和接受安慰剂组的检测参数变化进行批判性分析。还根据梗死部位分析了给予患者GIK后气体测量参数的变化。观察到，与初始检查相比，输注开始24小时后pH值升高，pCO2降低。这些变化与所应用的输注类型（GIK或生理盐水输注）无关，未观察到碳酸氢盐有显著变化。然而，与对照组相比，应用GIK输注后氧分压升高，且两组间差异具有统计学意义。无论是接受GIK治疗的组还是接受安慰剂的组，均未观察到梗死部位对酸碱平衡评估参数变化有任何影响。
