Warnock D H, Csapo A I
Prostaglandins. 1975 Oct;10(4):715-24. doi: 10.1016/s0090-6980(75)80019-0.
Of a total of 343 pregnant rats treated with the prostaglandin F2alpha analogue ICI 81008, 137 aborted, while 83 had reduced and 123 intact litter. These biological variations depended primarily on the gestational timing of treatment and on the dose and route of administration of this synthetic PG. In comparison with the 107 controls, all experimental rats which aborted had a drastic reduction in plasma progesterone levels which was highly significant (P is less than 0.001) until day 18. In contrast, those animals which escaped suboptimal ICI 81001 treatment with a partly resorbed litter, only had a moderate reduction in progesterone which was statistically significant (P is less than 0.01) until day 16 when levels of this steroid normally begin to decrease. Ineffective treatment did not affect progesterone levels and intact pregnancy. In contrast to progesterone, there was no correlation between plasma estradiol-17beta levels and the consequences of ICI 81008 treatment.
在总共343只接受前列腺素F2α类似物ICI 81008治疗的怀孕大鼠中，137只流产，83只产仔数减少，123只产仔数正常。这些生物学差异主要取决于治疗时的孕期以及这种合成前列腺素的剂量和给药途径。与107只对照大鼠相比，所有流产的实验大鼠血浆孕酮水平急剧下降，直到第18天，这种下降具有高度显著性（P<0.001）。相比之下，那些经ICI 81001次优治疗后产仔部分吸收但幸免的动物，孕酮仅适度下降，直到第16天具有统计学显著性（P<0.01），而此时该类固醇水平通常开始下降。无效治疗不影响孕酮水平和正常妊娠。与孕酮不同，血浆雌二醇-17β水平与ICI 81008治疗的结果之间没有相关性。
