Edgren R A, Gawlak D L, Stewart S
Prostaglandins. 1975 May;9(5):829-38. doi: 10.1016/0090-6980(75)90117-3.
Pregnancies in hamsters may be terminated by 10 mug PGF2alpha administered b.i.d. on days 4, k and 6 of gestation. Small (250 mug and above) daily injections of progesterone on the same days will reverse this PG effect; in contradistinction, 10 mg of progesterone per day failed to maintain normal pregnancies in hamsters spayed on day 5. Daily administration of 3 mg of progesterone and 1 mug of estrone essentially normalized the gestation; administration of PGF2alpha at 10 mg on days 5, 6 and 7 of pregnancy in steroid-maintained rats, resulted in pregnancy termination in all animals, while 1 mg was partly effective. These data demonstrate an extra-ovarian site of action of prostaglandin F2alpha on pregnancy in hamsters.
妊娠第4、5和6天，每天两次向仓鼠注射10微克前列腺素F2α可终止妊娠。在同一天每天注射小剂量（250微克及以上）孕酮可逆转这种前列腺素的作用；相反，每天10毫克孕酮未能维持在第5天切除卵巢的仓鼠的正常妊娠。每天给予3毫克孕酮和1微克雌酮可使妊娠基本正常化；在接受类固醇维持妊娠的大鼠妊娠第5、6和7天，注射10毫克前列腺素F2α可导致所有动物妊娠终止，而注射1毫克则部分有效。这些数据表明前列腺素F2α对仓鼠妊娠的作用位点在卵巢外。
