Marshall Diane, Haskard Dorian O
BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK.
Semin Immunol. 2002 Apr;14(2):133-40. doi: 10.1006/smim.2001.0350.
This article discusses the potential for clinical translation of the large amount of information on the molecular basis of leukocyte-endothelial cell interactions that has been collected over the last twenty years. Areas of current interest include the identification of adhesion molecule expression in inflammation by diagnostic imaging, understanding variability in inflammatory responsiveness and disease susceptibility through identification of adhesion molecule and chemokine polymorphisms and the application to the treatment of inflammatory diseases of monoclonal antibodies and conventional drugs with specific actions on leukocyte adhesion and migration.
本文探讨了在过去二十年中收集到的关于白细胞与内皮细胞相互作用分子基础的大量信息进行临床转化的潜力。当前感兴趣的领域包括通过诊断成像识别炎症中粘附分子的表达，通过识别粘附分子和趋化因子多态性来理解炎症反应性和疾病易感性的变异性，以及将对白细胞粘附和迁移具有特定作用的单克隆抗体和传统药物应用于炎症性疾病的治疗。
