Cook-Mills Joan M, Deem Tracy L
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267-0529, USA.
J Leukoc Biol. 2005 Apr;77(4):487-95. doi: 10.1189/jlb.0904554. Epub 2005 Jan 3.
Leukocyte migration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules and then migrate across the vascular endothelium. Endothelial cell adhesion molecules and their counter-receptors on leukocytes generate intracellular signals. This review focuses on the active function of endothelial cells during leukocyte-endothelial cell interactions. We include a discussion of the "outside-in" signals in endothelial cells, which are stimulated by antibody cross-linking or leukocyte binding to platelet-endothelial cell adhesion molecule-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1. Some of these signals in endothelial cells have been demonstrated to actively participate in leukocyte migration. We suggest that some of the adhesion molecule signals, which have not been assigned a function, are consistent with signals that stimulate retraction of lateral junctions, stimulate endothelial cell basal surface adhesion, or induce gene expression.
白细胞从血液迁移到组织对于免疫监视和炎症反应至关重要。在白细胞的这一穿壁过程中，白细胞与内皮细胞黏附分子结合，然后穿过血管内皮迁移。内皮细胞黏附分子及其在白细胞上的反受体产生细胞内信号。本综述聚焦于白细胞与内皮细胞相互作用过程中内皮细胞的主动功能。我们讨论了内皮细胞中的“外向内”信号，这些信号由抗体交联或白细胞与血小板内皮细胞黏附分子-1、细胞间黏附分子-1和血管细胞黏附分子-1的结合所刺激。内皮细胞中的一些此类信号已被证明积极参与白细胞迁移。我们认为，一些尚未明确功能的黏附分子信号与刺激侧向连接回缩、刺激内皮细胞基底表面黏附或诱导基因表达的信号一致。
