Augusto Ohara, Bonini Marcelo G, Amanso Angélica M, Linares Edlaine, Santos Célio C X, De Menezes Sílvia L
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil.
Free Radic Biol Med. 2002 May 1;32(9):841-59. doi: 10.1016/s0891-5849(02)00786-4.
Nitrogen dioxide and carbonate radical anion have received sporadic attention thus far from biological investigators. However, accumulating data on the biochemical reactions of nitric oxide and its derived oxidants suggest that these radicals may play a role in various pathophysiological processes. These potential roles are also indicated by recent studies on the high efficiency of urate and nitroxides in protecting cells and whole animals against the injury associated with conditions of excessive nitric oxide production. The high protective effects of these antioxidants are incompletely defined at the mechanistic level but some of them can be explained by their efficiency in scavenging peroxynitrite-derived radicals, particularly nitrogen dioxide and carbonate radical anion. In this review, we provide a framework for this hypothesis and discuss the potential sources and properties of these radicals that are likely to become increasingly recognized as important mediators of biological processes.
迄今为止，二氧化氮和碳酸根自由基阴离子只是偶尔受到生物学研究者的关注。然而，关于一氧化氮及其衍生氧化剂的生化反应的累积数据表明，这些自由基可能在各种病理生理过程中发挥作用。关于尿酸盐和氮氧化物在保护细胞和整个动物免受与一氧化氮产生过多相关的损伤方面的高效性的最新研究也表明了这些潜在作用。这些抗氧化剂的高保护作用在机制层面上尚未完全阐明，但其中一些可以通过它们清除过氧亚硝酸盐衍生自由基，特别是二氧化氮和碳酸根自由基阴离子的效率来解释。在这篇综述中，我们为这一假说提供了一个框架，并讨论了这些自由基的潜在来源和性质，它们可能会越来越被认为是生物过程的重要介质。
