Darvas F, Budai Z, Petöcz L, Kosóczky I
Res Commun Chem Pathol Pharmacol. 1975 Oct;12(2):243-54.
Quantitative relationships between chemical structures and locomotor activities of 20 substituted cycloalcanol basic ethers have been investigated using Hansch- and Free-Wilson methods. The Hansch-type regression analysis performed on 10 compounds having different cycloalkyl-rings revealed the highly significant role of the hydrophobic characteristics on the activity tested. The QSAR-study of 20 cycloalcanol-ethers according to Free and Wilson gave a significant equation with good statistical indices. On the basis of the results the compounds under study appear not to exert their activity through interaction with receptor raising strict sterical and electrical requirements.
采用汉施方法和自由-威尔逊方法，研究了20种取代环烷醇碱性醚的化学结构与运动活性之间的定量关系。对10种具有不同环烷基环的化合物进行的汉施型回归分析表明，疏水特性对所测试的活性具有高度显著的作用。根据弗里和威尔逊方法对20种环烷醇醚进行的定量构效关系研究得出了一个具有良好统计指标的显著方程。根据研究结果，所研究的化合物似乎不是通过与提出严格空间和电子要求的受体相互作用来发挥其活性的。
