Glasser A C
Methods Find Exp Clin Pharmacol. 1984 Oct;6(10):563-9.
The development of man's search for drugs from prehistoric times to the utilization of computerized Quantitative Structure-Activity Relationships is outlined in brief historical fashion. The development of the Hansch concept and the use of multiple regression analysis and the partition coefficient parameter are described in detail along with select examples of the use of the Hansch equation. Additional methods such as the Free-Wilson de novo method, as well as those ranging from the non-computerized methods of Topliss and Darvas to quite sophisticated interactive computer graphics, are presented in review.
本文以简短的历史形式概述了人类从史前时期到利用计算机化定量构效关系进行药物探索的发展历程。详细描述了汉施概念的发展、多元回归分析和分配系数参数的使用，并列举了汉施方程的应用实例。此外，还综述了其他方法，如Free-Wilson从头设计法，以及从托普利斯和达瓦斯的非计算机化方法到相当复杂的交互式计算机图形学方法等。
