Larsson I, Lindstedt E, Ohlin P, Strand S E, White T
Scand J Clin Lab Invest. 1975 Oct;35(6):517-24.
A scintillation camera technique was used for measuring renal uptake of [131I]Hippuran 80-110 s after injection. Externally measured Hippuran uptake was markedly influenced by kidney depth, which was measured by lateral-view image after injection of [99mTc]iron ascorbic acid complex or [197Hg]chlormerodrine. When one kidney was nearer to the dorsal surface of the body than the other, it was necessary to correct the externally measured Hippuran uptake for kidney depth to obtain reliable information on the true partition of Hippuran between the two kidneys. In some patients the glomerular filtration rate (GFR) was measured before and after nephrectomy. Measured postoperative GFR was compared with preoperatively predicted GFR, which was calculated by multiplying the preoperative Hippuran uptake of the kidney to be left in situ, as a fraction of the preoperative Hippuran uptake of both kidneys, by the measured preoperative GFR. The measured postoperative GFR was usually moderately higher than the preoperatively predicted GFR. The difference could be explained by a postoperative compensatory increase in function of the remaining kidney. Thus, the present method offers a possibility of estimating separate kidney function without arterial or ureteric catheterization.
采用闪烁照相机技术在注射[131I]马尿酸后80 - 110秒测量肾脏对其的摄取。外部测量的马尿酸摄取受到肾脏深度的显著影响，肾脏深度通过注射[99mTc]抗坏血酸铁络合物或[197Hg]氯汞君后的侧位图像来测量。当一侧肾脏比另一侧更靠近身体背侧表面时，有必要对外部测量的马尿酸摄取进行肾脏深度校正，以获得关于马尿酸在两侧肾脏间真实分配的可靠信息。在一些患者中，在肾切除术前和术后测量了肾小球滤过率（GFR）。将术后测量的GFR与术前预测的GFR进行比较，术前预测的GFR是通过将拟保留原位肾脏的术前马尿酸摄取量（占两侧肾脏术前马尿酸摄取总量的比例）乘以术前测量的GFR来计算的。术后测量的GFR通常比术前预测的GFR略高。这种差异可以用术后剩余肾脏功能的代偿性增加来解释。因此，本方法提供了一种无需动脉或输尿管插管即可估计单侧肾脏功能的可能性。
