Strand S E, Ljungberg M, Tennvall J, Norrgren K, Garkavij M
Department of Radiation Physics, Lund University Hospital, Sweden.
Med Biol Eng Comput. 1994 Sep;32(5):551-61. doi: 10.1007/BF02515314.
Results from therapeutic trials with radiolabelled monoclonal antibodies are difficult to compare, because of lack of accurate macroscopic and microscopic dosimetry for both tumours and normal tissues. Requirements for such a dosimetry are covered in the paper. Accurate in vivo dosimetric measurement techniques for verification of calculated absorbed doses are also needed to verify treatment planning. In the review, important topics related to dosimetry in therapeutic trials in RIT are covered, such as, absorbed-dose calculations and activity-quantification techniques for planar imaging and SPECT. The latter is particularly discussed, including a summary of different correction techniques. Absorbed-dose calculations and treatment-planning techniques are also discussed. Possible ways of enhancing the therapeutic ratio are reviewed, especially the novel technique with extracorporeal immuno-adsorption. The review could form the basis of the development of future treatment-planning protocols and for dosimetry calculations in radio-immunotherapy, considering some of the most important parameters for approaching an accurate in vivo dosimetry.
由于缺乏针对肿瘤和正常组织的准确宏观和微观剂量测定法，放射性标记单克隆抗体的治疗试验结果难以比较。本文涵盖了此类剂量测定法的要求。还需要准确的体内剂量测定技术来验证计算出的吸收剂量，以验证治疗计划。在这篇综述中，涵盖了与放射免疫治疗（RIT）治疗试验中剂量测定相关的重要主题，例如平面成像和单光子发射计算机断层扫描（SPECT）的吸收剂量计算及活度定量技术。特别讨论了后者，包括不同校正技术的总结。还讨论了吸收剂量计算和治疗计划技术。综述了提高治疗比的可能方法，尤其是体外免疫吸附新技术。考虑到实现准确体内剂量测定的一些最重要参数，该综述可为未来治疗计划方案的制定以及放射免疫治疗中的剂量测定计算奠定基础。
