Yasumoto M, Nonomura Y, Yoshimura R, Haraguchi K, Ito S, Ohashi I, Shibuya H
Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.
Skeletal Radiol. 2002 May;31(5):263-9. doi: 10.1007/s00256-002-0482-3. Epub 2002 Mar 23.
To assess the diagnostic accuracy of MR imaging for detecting bone marrow infiltration by malignant lymphoma.
Fifty-three patients with malignant lymphoma underwent MR imaging and bone marrow biopsy. In 80 iliac crests of the 53 patients (13 positive specimens in 9 patients and 67 negative specimens in 44 patients), biopsy results and the signal intensity characteristics were compared. MR sequences included T1-weighted SE, T2-weighted FSE with fat suppression, FSE STIR, and diffusion-weighted EPI with fat suppression at 1.5 T.
To detect lymphoma infiltration, T1-weighted SE had the highest sensitivity (92%) and diffusion-weighted EPI with fat suppression and FSE STIR had the highest specificity (92.5% and 92%, respectively). A combination of T1-weighted SE and FSE STIR yielded the highest sensitivity and specificity (85% and 97%, respectively). A combination of T1-weighted SE and FSE STIR sequences seems to be the current choice of imaging protocol for detecting bone marrow infiltration by malignant lymphoma.
评估磁共振成像（MR成像）检测恶性淋巴瘤骨髓浸润的诊断准确性。
53例恶性淋巴瘤患者接受了MR成像和骨髓活检。在这53例患者的80个髂嵴中（9例患者有13个阳性标本，44例患者有67个阴性标本），对活检结果和信号强度特征进行了比较。MR序列包括1.5T下的T1加权自旋回波（SE）序列、脂肪抑制的T2加权快速自旋回波（FSE）序列、FSE短反转恢复（STIR）序列以及脂肪抑制的扩散加权回波平面成像（EPI）序列。
为检测淋巴瘤浸润，T1加权SE序列具有最高的敏感性（92%），脂肪抑制的扩散加权EPI序列和FSE STIR序列具有最高的特异性（分别为92.5%和92%）。T1加权SE序列和FSE STIR序列联合使用时，敏感性和特异性最高（分别为85%和97%）。T1加权SE序列和FSE STIR序列联合似乎是目前检测恶性淋巴瘤骨髓浸润的成像方案选择。
