Becker M, Fritsch W P, Hausamen T U, Rotthauwe H W
Dtsch Med Wochenschr. 1976 Dec 3;101(49):1800-5. doi: 10.1055/s-0028-1104342.
Gastric acid secretion was measured in 20 infants aged 6-438 days. The values for the basal acid output and that after stimulation with 6 mug/kg pentagastrin subcutaneously were found to be related to age, body weight and body surface area. But these correlations were not comparable to those in adults. Standard values for different age groups in childhood must therefore be established. Furthermore, the results indicate parietal-cell immaturity during the first six months of life. Measurement of fasting serum-gastrin concentration by radioimmunoassay in 74 infants, aged 1-438 days, and 154 adults as controls revealed a high serum-gastrin level in infants, with an exponential decrease during the first year of life. Despite comparable pH values in gastric juice at one year of life, the gastrin concentrations were higher than those in adults (at a statistically significant level). On the other hand, normal serum-gastrin concentrations were found in ten pregnant women just before delivery. The results suggest a negative feed-back mechanism between gastric-acid secretion and fasting serum-gastrin levels, but such mechanism probably being limited by extragastric gastrin secretion.
对20名年龄在6至438天的婴儿进行了胃酸分泌测量。发现基础酸排出量以及皮下注射6微克/千克五肽胃泌素后的酸排出量值与年龄、体重和体表面积相关。但这些相关性与成年人的不同。因此，必须建立儿童不同年龄组的标准值。此外，结果表明在生命的前六个月壁细胞不成熟。通过放射免疫分析法对74名年龄在1至438天的婴儿和154名作为对照的成年人进行空腹血清胃泌素浓度测量，结果显示婴儿血清胃泌素水平较高，在生命的第一年呈指数下降。尽管一岁时胃液的pH值相当，但胃泌素浓度高于成年人（具有统计学显著水平）。另一方面，在十名即将分娩的孕妇中发现血清胃泌素浓度正常。结果提示胃酸分泌与空腹血清胃泌素水平之间存在负反馈机制，但这种机制可能受胃外胃泌素分泌的限制。
