Crabtree Gerald R, Olson Eric N
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Cell. 2002 Apr;109 Suppl:S67-79. doi: 10.1016/s0092-8674(02)00699-2.
Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA. Nuclear import is opposed by kinases such as GSK3, thereby rendering transcription continuously responsive to receptor occupancy. Disruptions of the genes involved in NFAT signaling are implicating this pathway as a regulator of developmental cell-cell interactions.
钙信号激活磷酸酶钙调神经磷酸酶，并诱导NFATc蛋白进入细胞核，在细胞核中它们与其他蛋白协同作用，在DNA上形成复合物。核输入受到诸如GSK3等激酶的抑制，从而使转录持续响应受体占据情况。参与NFAT信号传导的基因的破坏表明该途径是发育中细胞间相互作用的调节因子。
