活化T细胞核因子（NFAT）蛋白作为疾病中的靶向分子：一篇叙述性综述。
Nuclear Factor of Activated T Cells (NFAT) Proteins as Targeted Molecules in Diseases: A Narrative Review.
作者信息
Mozafari Mohadese, Md Hashim Siti Nurnasihah, Ahmad Amin Noordin Khairul Bariah, Zainal Siti Aishah, Azlina Ahmad
机构信息
Basic and Medical Sciences Unit, School of Dental Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, MYS.
Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, MYS.
出版信息
Cureus. 2024 Dec 16;16(12):e75844. doi: 10.7759/cureus.75844. eCollection 2024 Dec.
The nuclear factor of activated T cells (NFAT) is a key player in the NFAT pathway, regulating various cellular processes physiologically and pathologically. NFAT signaling is implicated in developing multiple diseases, such as cancer progression, that are associated with angiogenesis. Despite numerous studies on NFAT, there is still a dearth of information on the proteins and signaling pathway compared to other established pathways. With five NFAT proteins in the spotlight, this review aims to update the understanding of their roles and signaling by analyzing the most recent studies on the NFAT pathway. The recent insights into NFAT proteins and their association with diseases enhance our understanding of these proteins and open the possibility of developing therapeutic strategies for such diseases.
活化T细胞核因子（NFAT）是NFAT信号通路中的关键因子，在生理和病理状态下调节多种细胞过程。NFAT信号传导与多种疾病的发生发展有关，如与血管生成相关的癌症进展。尽管对NFAT进行了大量研究，但与其他已确立的信号通路相比，关于其相关蛋白和信号通路的信息仍然匮乏。鉴于五种NFAT蛋白备受关注，本综述旨在通过分析NFAT信号通路的最新研究成果，更新对其作用和信号传导的认识。对NFAT蛋白及其与疾病关联的最新见解，加深了我们对这些蛋白的理解，并为开发针对此类疾病的治疗策略开辟了可能性。
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