Xu Weidong, Hofmann-Lehmann Regina, McClure Harold M, Ruprecht Ruth M
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
Vaccine. 2002 May 6;20(15):1956-60. doi: 10.1016/s0264-410x(02)00077-4.
Passive immunization with synergistic combinations of human monoclonal antibodies (mAbs) directed against conserved epitopes of the human immunodeficiency virus (HIV) envelope completely protected 13 out of 16 rhesus monkeys challenged intravenously or orally with chimeric simian-human immunodeficiency virus (SHIV) strains; partial protection was seen in another two. A high degree of protection was seen among orally challenged neonates. Thus, we propose that passive immunization with synergistic combinations of neutralizing human mAbs may be effective in preventing maternal HIV transmission when given as post-exposure prophylaxis at birth and as prophylaxis against milk-borne transmission. Because we only used mAbs with well-defined epitope specificities, our studies also yield key information for designing AIDS vaccines: the correlates of immune protection. Vaccine strategies that can evoke antibody responses to epitopes recognized by the mAbs used in our primate studies could be important components of successful AIDS vaccines.
用针对人类免疫缺陷病毒（HIV）包膜保守表位的人单克隆抗体（mAb）协同组合进行被动免疫，可使16只经静脉或口服感染嵌合型猿猴-人类免疫缺陷病毒（SHIV）毒株的恒河猴中的13只获得完全保护；另有2只获得部分保护。在经口感染的新生猴中也观察到高度保护作用。因此，我们提出，在出生时进行暴露后预防以及预防经母乳传播时，用中和性人mAb协同组合进行被动免疫可能有效预防母婴HIV传播。由于我们仅使用了表位特异性明确的mAb，我们的研究还为设计艾滋病疫苗提供了关键信息：免疫保护的相关因素。能够引发针对我们在灵长类动物研究中所用mAb识别的表位产生抗体反应的疫苗策略，可能是成功的艾滋病疫苗的重要组成部分。
