Bell L T, Branstrator M, Roux C, Hurley L S
Teratology. 1975 Dec;12(3):221-6. doi: 10.1002/tera.1420120302.
The effect of dietary deficiency during pregnancy of zinc or magnesium on maternal and fetal chromosomes was studied. Pregnant rats were given a zinc-deficient or a magnesium-deficient diet from the beginning of pregnancy and maternal bone marrow and fetal liver were removed on day 19 of gestation. Chromosome spreads were prepared and metaphases examined for abnormalities. Both magnesium- and zinc-deficient maternal bone-marrow and fetal liver cells showed significantly more chromosomal abnormalities than did those of controls. The chromosomal aberrations occurring in highest incidence in magnesium-deficient animals were terminal deletions and fragments. A higher than normal incidence of "stickiness" was also observed in cells from magnesium-deficient animals. In zinc-deficient animals, on the other hand, the chromosomal aberrations with the highest incidence were gaps and terminal deletions.
研究了孕期锌或镁缺乏饮食对母体和胎儿染色体的影响。从怀孕开始，给怀孕大鼠喂食缺锌或缺镁饮食，并在妊娠第19天取出母体骨髓和胎儿肝脏。制备染色体涂片并检查中期染色体有无异常。与对照组相比，缺镁和缺锌的母体骨髓及胎儿肝细胞均显示出明显更多的染色体异常。缺镁动物中发生率最高的染色体畸变是末端缺失和片段。在缺镁动物的细胞中还观察到高于正常发生率的“粘连”现象。另一方面，在缺锌动物中，发生率最高的染色体畸变是裂隙和末端缺失。
