El Nahas S M, Samad M F, de Hondt H A
Department of Cell Biology, National Research Center, Cairo, Egypt.
Environ Mol Mutagen. 1997;29(1):53-7.
Cidial, an organophosphorous insecticide (also known as phenthoate), was tested for its genotoxic effect on both maternal and fetal cells. Cidial was administered at three different dose levels (53.5, 106.9, and 171 mg/kg) to pregnant mice on day 16 of gestation. Maternal bone marrow and embryonic liver cells were examined for chromosomal aberrations and cellular proliferation. Cidial was found to increase the percentage of cells with chromosomal aberrations in both mothers and fetuses. It also significantly inhibited the rate of mitotic activity of both maternal and fetal cells, with the inhibitory effect being more appreciable in fetal cells than in maternal cells. The data indicate that cidial, which is widely used in rural areas, is hazardous to both mothers and their transplacentally exposed babies.
西地亚，一种有机磷杀虫剂（也称为稻丰散），对母体和胎儿细胞的遗传毒性作用进行了测试。在妊娠第16天，以三种不同剂量水平（53.5、106.9和171毫克/千克）给怀孕小鼠施用西地亚。检查母体骨髓和胚胎肝细胞的染色体畸变和细胞增殖情况。发现西地亚会增加母体和胎儿中具有染色体畸变的细胞百分比。它还显著抑制母体和胎儿细胞的有丝分裂活性，对胎儿细胞的抑制作用比对母体细胞更明显。数据表明，在农村地区广泛使用的西地亚对母亲及其经胎盘暴露的婴儿均有危害。
