Wedzony K, Czepiel K, Fijał K
Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Pol J Pharmacol. 2001 Nov-Dec;53(6):675-9.
Non-fluorescent, double-labeling techniques were used in order to investigate whether NMDAR1 receptor subunits are localized on dopaminergic (i.e. tyrosine hydroxylase-positive) neurons of the rat substantia nigra, pars compacta. It has been found that NMDAR1 receptor subunits are highly abundant in the pars compacta neurons and their dendritic processes. It was also found that vast majority, if not all, of pars compacta neurons which are positive for the presence of NMDAR1 receptor subunits are dopaminergic ones. It is concluded that if NMDAR1 receptor subunits, an indispensable element of functional NMDA receptor ion channel complex, is co-assembled with other subunits of NMDA receptor ion channel complex, NMDA receptors might directly control the activity of dopaminergic neurons.
为了研究NMDAR1受体亚基是否定位于大鼠黑质致密部的多巴胺能（即酪氨酸羟化酶阳性）神经元上，采用了非荧光双标记技术。研究发现，NMDAR1受体亚基在致密部神经元及其树突过程中高度丰富。还发现，几乎所有存在NMDAR1受体亚基的致密部神经元都是多巴胺能神经元。由此得出结论，如果作为功能性NMDA受体离子通道复合物不可或缺的元素的NMDAR1受体亚基与NMDA受体离子通道复合物的其他亚基共同组装，NMDA受体可能直接控制多巴胺能神经元的活动。
