新型γ-氨基丁酸酰胺衍生物及其邻苯二甲酰亚胺前体对小鼠中枢神经系统活性的影响。
Influence of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors on the central nervous system activity in mice.
作者信息
Mendyk A, Sałat K, Librowski T, Czarneck R, Malawska B
机构信息
Department of Pharmacodynamics, Jagiellonian University, Medical College, Kraków, Poland.
出版信息
Pol J Pharmacol. 2001 Nov-Dec;53(6):689-93.
The present study investigated the influence of BM-78, BM-121 (gamma-aminobutyric acid amide derivatives) and BM-42, BM-43 (phthalimide precursors of BM-78 and BM-121) on the spontaneous locomotor activity and on the picrotoxin-induced seizures. Results of pharmacological in vivo examination of the effects of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors (compounds BM-78, BM-121, BM-42, BM-43), presented in this paper showed that all the compounds had different but clear influence on CNS in mice.
本研究调查了BM - 78、BM - 121（γ-氨基丁酸酰胺衍生物）以及BM - 42、BM - 43（BM - 78和BM - 121的邻苯二甲酰亚胺前体）对自发运动活性以及对印防己毒素诱发癫痫发作的影响。本文展示的关于新型γ-氨基丁酸酰胺衍生物及其邻苯二甲酰亚胺前体（化合物BM - 78、BM - 121、BM - 42、BM - 43）效应的体内药理学检查结果表明，所有这些化合物对小鼠中枢神经系统均有不同但明确的影响。
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