新型γ-氨基丁酸单萜同系物对小鼠中枢神经系统活性的影响。
Influence of new monoterpene homologues of GABA on the central nervous system activity in mice.
作者信息
Librowski T, Czarnecki R, Mendyk A, Jastrzebska M
机构信息
Department of Pharmacodynamics, Medical College, Jagiellonian University, Kraków, Poland.
出版信息
Pol J Pharmacol. 2000 Jul-Aug;52(4):317-21.
PMID:11345489
Abstract
This behavioral study in mice showed that the monoterpene homologues of GABA (SL-1, SL-2 and SL-3), characterized by low toxicity, induced an increase in spontaneous locomotor activity (SL-2 and SL-3). Moreover, SL-3 shortened hexobarbital-induced sleeping time, and SL-1 showed anticonvulsant activity in pentetrazole-induced seizures.
摘要
这项针对小鼠的行为学研究表明，γ-氨基丁酸（GABA）的单萜同系物（SL-1、SL-2和SL-3）具有低毒性，可诱导自发运动活动增加（SL-2和SL-3）。此外，SL-3缩短了己巴比妥诱导的睡眠时间，SL-1在戊四氮诱导的癫痫发作中表现出抗惊厥活性。
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