Chadzinska M, Maj M, Scislowska-Czarnecka A, Przewłocka B, Plytycz B
Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, Kraków, Poland.
Pol J Pharmacol. 2001 Nov-Dec;53(6):715-8.
Zymosan- or thioglycollate-induced experimental peritoneal inflammation in mice may serve as a convenient model for investigations of involvement of opioid peptides derived from exudatory leukocytes in the inflammatory processes. During peritonitis, the influx of neutrophils and monocytes/macrophages correlated with a sequential appearance of proinflammatory cytokines (IL-1beta and TNFalpha). After both kinds of stimulation, the expression of PENK mRNA was much higher in exudatory peritoneal leukocytes than its basal level in steady state.
酵母聚糖或巯基乙酸盐诱导的小鼠实验性腹膜炎，可作为一个方便的模型，用于研究渗出性白细胞衍生的阿片肽在炎症过程中的作用。在腹膜炎期间，中性粒细胞和单核细胞/巨噬细胞的流入与促炎细胞因子（IL-1β和TNFα）的相继出现相关。在两种刺激后，渗出性腹膜白细胞中PENK mRNA的表达比其稳态下的基础水平高得多。
