Moss R B, Wallace M R, Steigbigel R T, Morrison S A, Giermakowska W K, Nardo C J, Diveley J P, Carlo D J
The Immune Response Corporation, Carlsbad, CA 92008, USA.
Clin Exp Immunol. 2002 May;128(2):359-64. doi: 10.1046/j.1365-2249.2002.01835.x.
We treated a cohort of 38 HIV-infected individuals with a therapeutic vaccine (REMUNE, HIV-1 Immunogen) in an open label study. We then determined whether baseline parameters, such as CD4 cell count, viral load and IgG levels, were predictive of the magnitude of the HIV-specific lymphocyte proliferative responses (LPRs). We demonstrate herein that there is a significant enhancement from baseline for both HIV and p24 antigen-stimulated LPRs after immunization. Using a responder definition of a stimulation index of >5 on at least two post-immunization time-points, 29/38 (76%) responded to HIV-1 antigen while 27/38 (71%) responded to native p24 antigen. Viral load and total IgG were negatively correlated, while CD4 cell counts were positively associated with the magnitude of the HIV antigen LPR. In a multivariable analysis, baseline CD4 was the best predictor of HIV antigen LPR post-immunization.
在一项开放标签研究中，我们用一种治疗性疫苗（REMUNE，HIV-1免疫原）治疗了38名HIV感染个体的队列。然后我们确定基线参数，如CD4细胞计数、病毒载量和IgG水平，是否能预测HIV特异性淋巴细胞增殖反应（LPR）的程度。我们在此证明，免疫后HIV和p24抗原刺激的LPR与基线相比均有显著增强。使用在至少两个免疫后时间点刺激指数>5的应答者定义，29/38（76%）对HIV-1抗原产生应答，而27/38（71%）对天然p24抗原产生应答。病毒载量与总IgG呈负相关，而CD4细胞计数与HIV抗原LPR的程度呈正相关。在多变量分析中，基线CD4是免疫后HIV抗原LPR的最佳预测指标。
