Miller Tandy J, McGlashan Thomas H, Rosen Joanna Lifshey, Somjee Lubna, Markovich Philip J, Stein Kelly, Woods Scott W
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA.
Am J Psychiatry. 2002 May;159(5):863-5. doi: 10.1176/appi.ajp.159.5.863.
This study was conducted to determine the interrater reliability and predictive validity of a set of diagnostic criteria for the prodrome of the first episode of schizophrenic psychosis when based on the Structured Interview for Prodromal Syndromes.
The subjects were patients referred for evaluation because of a suspected schizophrenia prodromal syndrome. For the reliability study, two to four raters independently diagnosed 18 patients on the basis of face-to-face or videotaped interviews. For the validity study, 6- and 12-month outcome data were collected for 29 patients.
Agreement in differentiating prodromal from nonprodromal patients was 93%. The prodromal features had converted to schizophrenic psychosis for 46% of the prodromal patients at 6 months and for 54% at 12 months.
In small groups of subjects, these diagnostic criteria for the schizophrenic prodrome and the Structured Interview for Prodromal Syndromes showed promising interrater reliability and predictive validity.
本研究旨在确定基于前驱症状结构化访谈制定的一组精神分裂症精神病首次发作前驱期诊断标准的评分者间信度和预测效度。
研究对象为因疑似精神分裂症前驱综合征而被转诊评估的患者。在信度研究中，两至四名评分者基于面对面访谈或录像访谈对18名患者进行独立诊断。在效度研究中，收集了29名患者6个月和12个月时的转归数据。
区分前驱期患者与非前驱期患者的一致性为93%。6个月时，46%的前驱期患者的前驱症状转变为精神分裂症精神病，12个月时为54%。
在小样本受试者中，这些精神分裂症前驱期诊断标准及前驱症状结构化访谈显示出了良好的评分者间信度和预测效度。
