Murray Conor H, Danesh Kaihan, Cooper Ziva D
UCLA Center for Cannabis and Cannabinoids, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA USA.
Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA USA.
NPP Digit Psychiatry Neurosci. 2025;3(1):18. doi: 10.1038/s44277-025-00039-8. Epub 2025 Jul 3.
Healthy individuals that use cannabis are at greater risk of developing mental health conditions than those that do not use cannabis. Here, using mobile electroencephalography (EEG) in controlled laboratory settings, we examined two putative biomarkers of mental health across two studies of people who use cannabis ( = 100, 50% male; = 40, 60% male). We examined associations to cannabis use and mood and assessed the influence of sex and age on the outcomes. Specifically, in the first study, we examined prefrontal broadband power, previously found to be related to healthy neurocognitive development, in relation cannabis use. We also examined left prefrontal alpha power, previously found to be related to anxiety and depression, in relation to Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) scores. In the second study, we examined only left prefrontal alpha power during the cold pressor test (CPT), which elicits a stress response. We found that in the first study, young males (ages 21-23) showed the greatest association between prefrontal broadband power and cannabis use (R = 0.50; = 0.007), while females showed associations between left prefrontal alpha power and BAI scores (R = 0.61, = 0.013). In the second study, the CPT increased anxiousness ( < 0.001) but did not affect left prefrontal alpha power. Together, our findings help to characterize these putative biomarkers in individuals that use cannabis, while informing the utility of mobile EEG devices for tracking markers of mental health and wellness outside of laboratory settings.
与不使用大麻的人相比，使用大麻的健康个体患心理健康问题的风险更高。在此，我们在受控实验室环境中使用移动脑电图（EEG），在两项针对使用大麻的人群的研究中（n = 100，50%为男性；n = 40，60%为男性），研究了心理健康的两种假定生物标志物。我们研究了与大麻使用和情绪的关联，并评估了性别和年龄对结果的影响。具体而言，在第一项研究中，我们研究了前额叶宽带功率（先前发现与健康的神经认知发育有关）与大麻使用的关系。我们还研究了左前额叶α功率（先前发现与焦虑和抑郁有关）与贝克抑郁量表（BDI）和贝克焦虑量表（BAI）得分的关系。在第二项研究中，我们仅在冷加压试验（CPT）期间研究了左前额叶α功率，该试验会引发应激反应。我们发现，在第一项研究中，年轻男性（21 - 23岁）在前额叶宽带功率与大麻使用之间表现出最强的关联（R = 0.50；p = 0.007），而女性则表现出左前额叶α功率与BAI得分之间的关联（R = 0.61，p = 0.013）。在第二项研究中，CPT增加了焦虑感（p < 0.001），但未影响左前额叶α功率。总之，我们的研究结果有助于刻画使用大麻个体中的这些假定生物标志物，同时为移动EEG设备在实验室环境之外跟踪心理健康和幸福指标的效用提供信息。
