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恶性疟原虫疟疾患者血浆中可溶性CD30水平升高。

Increased levels of soluble CD30 in plasma of patients with Plasmodium falciparum malaria.

作者信息

Kemp Kåre, Kurtzhals Jørgen A L, Akanmori Bartholomew D, Adabayeri Victoria, Goka Bamenla Q, Behr Charlotte, Hviid Lars

机构信息

Center for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark.

出版信息

Clin Diagn Lab Immunol. 2002 May;9(3):720-2. doi: 10.1128/cdli.9.3.720-722.2002.

DOI:10.1128/cdli.9.3.720-722.2002
PMID:11986285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC119977/
Abstract

Levels of soluble CD30 (sCD30) in serum were elevated in patients with Plasmodium falciparum malaria but showed decline following treatment. The levels of sCD30 in serum were correlated significantly with the expression of gamma interferon by peripheral T cells. These data suggest that CD30(+) cells are upregulated during a malaria attack and that they may play a regulating role at the site of inflammation.

摘要

恶性疟原虫疟疾患者血清中可溶性CD30(sCD30)水平升高,但治疗后呈下降趋势。血清中sCD30水平与外周血T细胞γ干扰素的表达显著相关。这些数据表明,CD30(+)细胞在疟疾发作期间上调,并且它们可能在炎症部位发挥调节作用。

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引用本文的文献

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PLoS One. 2017 Apr 3;12(4):e0174718. doi: 10.1371/journal.pone.0174718. eCollection 2017.

本文引用的文献

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Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria.恶性疟原虫疟疾治疗患者T细胞中的细胞因子产生与凋亡
Clin Exp Immunol. 2002 Jan;127(1):151-7. doi: 10.1046/j.1365-2249.2002.01714.x.
2
Identification of IFN-gamma-producing CD4+ T cells following PMA stimulation.佛波酯(PMA)刺激后产生γ干扰素的CD4 + T细胞的鉴定。
J Interferon Cytokine Res. 2001 Jul;21(7):503-6. doi: 10.1089/10799900152434376.
3
Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases.CD30 + T细胞在类风湿性关节炎中的作用:Th1驱动疾病的一种反调节模式
Trends Immunol. 2001 Feb;22(2):72-7. doi: 10.1016/s1471-4906(00)01829-9.
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Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians.
Mech Ageing Dev. 2000 Dec 20;121(1-3):37-46. doi: 10.1016/s0047-6374(00)00195-0.
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Engagement of CD30 shapes the secretion of cytokines by human gamma delta T cells.CD30 的激活塑造了人类 γδ T 细胞的细胞因子分泌。
Eur J Immunol. 2000 Aug;30(8):2172-80. doi: 10.1002/1521-4141(2000)30:8<2172::AID-IMMU2172>3.0.CO;2-P.
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Peripheral T lymphocyte cytokine profile (IFNgamma, IL-2, IL-4) and CD30 expression/release during measles infection.麻疹感染期间外周血T淋巴细胞细胞因子谱(IFNγ、IL-2、IL-4)及CD30表达/释放情况
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Progressive polarization towards a T helper/cytotoxic type-1 cytokine pattern during age-dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration.在免疫反应的年龄依赖性成熟过程中,向辅助性T细胞/细胞毒性1型细胞因子模式的渐进性极化与CD30细胞表达及血清浓度呈负相关。
Clin Exp Immunol. 1999 Aug;117(2):291-7. doi: 10.1046/j.1365-2249.1999.00977.x.
8
Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria.与脑型疟疾和非重症疟疾相比,重症疟疾贫血患者血浆中白细胞介素10浓度较低。
Lancet. 1998 Jun 13;351(9118):1768-72. doi: 10.1016/S0140-6736(97)09439-7.
9
Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines.共刺激受体CD30的表达受CD28和细胞因子的共同调控。
J Immunol. 1998 Mar 1;160(5):2180-7.
10
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J Immunol. 1997 Mar 1;158(5):2090-8.