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恶性疟原虫疟疾患者血浆中可溶性CD30水平升高。

Increased levels of soluble CD30 in plasma of patients with Plasmodium falciparum malaria.

作者信息

Kemp Kåre, Kurtzhals Jørgen A L, Akanmori Bartholomew D, Adabayeri Victoria, Goka Bamenla Q, Behr Charlotte, Hviid Lars

机构信息

Center for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark.

出版信息

Clin Diagn Lab Immunol. 2002 May;9(3):720-2. doi: 10.1128/cdli.9.3.720-722.2002.

Abstract

Levels of soluble CD30 (sCD30) in serum were elevated in patients with Plasmodium falciparum malaria but showed decline following treatment. The levels of sCD30 in serum were correlated significantly with the expression of gamma interferon by peripheral T cells. These data suggest that CD30(+) cells are upregulated during a malaria attack and that they may play a regulating role at the site of inflammation.

摘要

恶性疟原虫疟疾患者血清中可溶性CD30(sCD30)水平升高,但治疗后呈下降趋势。血清中sCD30水平与外周血T细胞γ干扰素的表达显著相关。这些数据表明,CD30(+)细胞在疟疾发作期间上调,并且它们可能在炎症部位发挥调节作用。

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