Jakobsen P H, Morris-Jones S, Theander T G, Hviid L, Hansen M B, Bendtzen K, Ridley R G, Greenwood B M
Department of Infectious Diseases, University Hospital (Righospitalet), Copenhagen, Denmark.
Clin Exp Immunol. 1994 Apr;96(1):98-103. doi: 10.1111/j.1365-2249.1994.tb06237.x.
Plasma samples from children with mild and severe Plasmodium falciparum malaria and from children with unrelated diseases were collected to investigate whether the clinical outcome of infection was associated with plasma factors which reflected the activity of different cells of the immune system. Children with severe P. falciparum malaria had significantly higher plasma levels of soluble IL-2R than children with mild malaria. Plasma levels of IL-2R and levels of parasitaemia were significantly correlated. Neither parasitaemia nor plasma levels of tumour necrosis factor-alpha (TNF-alpha), IL-6, lymphotoxin (LT), interferon-gamma (IFN-gamma), IL-4, soluble IL-4R or soluble CD8 differed significantly between the two groups of children with malaria. High plasma levels of soluble CD8 were associated with failure of lymphocytes to produce IFN-gamma in vitro following stimulation with P. falciparum antigen. We conclude that soluble IL-2R is a useful marker of disease severity independently of the association with levels of parasitaemia, and that functional regulation of different lymphocyte subsets occurs during acute malaria episodes.
收集了患有轻度和重度恶性疟原虫疟疾的儿童以及患有无关疾病的儿童的血浆样本，以研究感染的临床结果是否与反映免疫系统不同细胞活性的血浆因子相关。患有重度恶性疟原虫疟疾的儿童血浆中可溶性白细胞介素-2受体（IL-2R）水平显著高于患有轻度疟疾的儿童。IL-2R的血浆水平与疟原虫血症水平显著相关。两组患疟疾儿童的疟原虫血症水平、肿瘤坏死因子-α（TNF-α）、白细胞介素-6、淋巴毒素（LT）、干扰素-γ（IFN-γ）、白细胞介素-4、可溶性白细胞介素-4受体或可溶性CD8的血浆水平均无显著差异。血浆中可溶性CD8水平高与淋巴细胞在受到恶性疟原虫抗原刺激后体外产生IFN-γ的功能失败有关。我们得出结论，可溶性IL-2R是疾病严重程度的一个有用标志物，独立于与疟原虫血症水平的关联，并且在急性疟疾发作期间不同淋巴细胞亚群发生功能调节。
