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肺炎克雷伯菌脂多糖的结构。核心与多糖O链之间连接区域结构的阐明以及O链非还原端残基的鉴定。

Structures of lipopolysaccharides from Klebsiella pneumoniae. Eluicidation of the structure of the linkage region between core and polysaccharide O chain and identification of the residues at the non-reducing termini of the O chains.

作者信息

Vinogradov Evgeny, Frirdich Emilisa, MacLean Leann L, Perry Malcolm B, Petersen Bent O, Duus Jens Ø, Whitfield Chris

机构信息

Institute for Biological Sciences, National Research Council, Ottawa, Ontario K1A 0R6, Canada.

出版信息

J Biol Chem. 2002 Jul 12;277(28):25070-81. doi: 10.1074/jbc.M202683200. Epub 2002 May 1.

DOI:10.1074/jbc.M202683200
PMID:11986326
Abstract

Deamination of LPSs from Klebsiella pneumoniae released O-chain polysaccharides together with a fragment of the core oligosaccharide. The structures of the products from serotypes O1, O2a, O2a,c, O3, O4, O5, and O12 were determined by NMR spectroscopy and chemical methods, identifying the linkage region between the O antigens and the core as well as novel residues at the non-reducing ends of the polysaccharides. All serotypes had an identical linkage between the O chain and core.

摘要

肺炎克雷伯菌脂多糖的脱氨作用释放出O-链多糖以及核心寡糖片段。通过核磁共振光谱法和化学方法确定了血清型O1、O2a、O2a,c、O3、O4、O5和O12产物的结构，确定了O抗原与核心之间的连接区域以及多糖非还原端的新残基。所有血清型的O链与核心之间的连接均相同。

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