Hernández-Hernández R, Velasco M, Armas-Hernández M J, Armas-Padilla M C
Clinical Pharmacology Unit, School of Medicine, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Venezuela.
J Hum Hypertens. 2002 Mar;16 Suppl 1:S114-7. doi: 10.1038/sj.jhh.1001355.
Calcium antagonists represent an important group of drugs for the treatment of hypertension; they are effective in the whole range of severity of the disease. Dihy- dropyridine derivatives are most frequently used, and can be used in association with other antihypertensive drugs; meanwhile phenylalkylamines and benzothiazepines are contraindicated in association with beta-blocker drugs. Calcium antagonists with slow starting effect and long duration of action are the choice for use in long-term antihypertensive treatment. This group of drugs is specially indicated in elderly patients, in those with diabetes mellitus and in patients with coronary heart disease. Phenylalkylamines and benzothiazepine derivatives are also used in patients with supraventricular arrhythmias. This group of agents is as safe as diuretics, angiotensin-converting enzyme-inhibitors and beta-blocking drugs in the long-term treatment of hypertension.
钙拮抗剂是治疗高血压的一类重要药物；它们对疾病的整个严重程度范围都有效。二氢吡啶衍生物使用最为频繁，可与其他抗高血压药物联合使用；同时，苯烷基胺类和苯并硫氮䓬类与β受体阻滞剂联合使用时禁用。起效缓慢、作用持续时间长的钙拮抗剂是长期抗高血压治疗的首选药物。这类药物特别适用于老年患者、糖尿病患者和冠心病患者。苯烷基胺类和苯并硫氮䓬衍生物也用于治疗室上性心律失常患者。在高血压的长期治疗中，这类药物与利尿剂、血管紧张素转换酶抑制剂和β受体阻滞剂一样安全。
