Pitche P, Wolkenstein P, Cremer G, Foulet F, Lascaux A S, Revuz J
Services de Dermatologie, Hôpital Henri-Mondor, 94010 Créteil Cedex.
Ann Dermatol Venereol. 2002 Mar;129(3):287-9.
In vitro exposure to benzyl benzoate (25 p. 100) kills Sarcoptes scabiei within three hours. The aim of our study was to determine in vivo elimination of Sarcopte scabiei with a benzyl benzoate-sulfiram association.
Medical charts of patients hospitalized for disseminated scabies from 1993 to 1999 were reviewed retrospectively. The diagnosis of scabies was confirmed by microscopic determination. Parasitological examinations were conducted every day or every two days until negative results. Patients were treated by successive applications of benzyl benzoate until parasitological cure.
Twenty patients were included in the study. The median delay of parasitological cure was seven days. After 15 days, 95 p. 100 of patients were cured. Two cutaneous side-effects were reported.
Despite immediate in vitro efficacy, benzyl benzoate action is delayed in vivo. The time of parasitological negativation after one application of benzyl benzoate is unknown. Therefore, it is not currently possible to determine whether our therapeutic regimen was excessive or not.
体外接触苯甲酸苄酯（25%）可在三小时内杀死疥螨。我们研究的目的是确定苯甲酸苄酯与磺胺联合使用时对体内疥螨的清除效果。
回顾性分析1993年至1999年因播散性疥疮住院患者的病历。疥疮诊断通过显微镜检查确诊。每天或每两天进行寄生虫学检查，直至结果为阴性。患者通过连续涂抹苯甲酸苄酯进行治疗，直至寄生虫学治愈。
20名患者纳入研究。寄生虫学治愈的中位时间为7天。15天后，95%的患者治愈。报告了2例皮肤副作用。
尽管苯甲酸苄酯在体外有即时疗效，但其在体内的作用延迟。单次涂抹苯甲酸苄酯后寄生虫学转阴的时间未知。因此，目前无法确定我们的治疗方案是否过度。
