Haustein U F, Hlawa B
Department of Dermatology, School of Medicine, Karl Marx University, Leipzig, GDR.
Acta Derm Venereol. 1989;69(4):348-51.
This open clinical study was designed to evaluate and compare the efficacy and side effects of lindane (1% and 0.3%), benzyl benzoate (20% and 10%) and permethrin (5% and 2.5%) after two, three, and one application at bedtime, in the treatment of scabies in 114 adults and 80 children aged between 0 and 5 years. Treatment failures were registered after lindane in 3 adults and 2 children, whereas benzyl benzoate and permethrin cured all patients as assessed after a 3-week follow-up. The number of irritations and post-scabious eczematous reactions was increased after benzyl benzoate treatment. Permethrin proved to be very reliable and exhibited few side effects when applied once at bedtime. Because of the percutaneous absorption and neurotoxicity of lindane, the application of permethrin can be recommended as a useful alternative in premature infants and small children, patients with seizures and neurological complications, in cases of therapeutic failure with lindane the treatment needs to be repeated, in scabies crustosa, as well as in children, pregnant women and nursing mothers.
这项开放性临床研究旨在评估和比较林丹（1%和0.3%）、苯甲酸苄酯（20%和10%）和氯菊酯（5%和2.5%）在睡前分别用药两次、三次和一次后，对114名成人和80名0至5岁儿童疥疮的治疗效果及副作用。使用林丹治疗后，有3名成人和2名儿童治疗失败，而在3周的随访评估中，苯甲酸苄酯和氯菊酯治愈了所有患者。苯甲酸苄酯治疗后，刺激和疥疮后湿疹反应的数量增加。氯菊酯被证明非常可靠，睡前使用一次时副作用很少。由于林丹的经皮吸收和神经毒性，对于早产儿、幼儿、癫痫和神经系统并发症患者、林丹治疗失败需要重复治疗的情况、结痂性疥疮患者以及儿童、孕妇和哺乳期妇女，推荐使用氯菊酯作为一种有效的替代药物。
