p53、bcl-2和Ki-67免疫反应性以及细胞凋亡在正常口腔上皮、口腔癌前病变和恶性病变中的发生率。
Prevalence of p53, bcl-2, and Ki-67 immunoreactivity and of apoptosis in normal oral epithelium and in premalignant and malignant lesions of the oral cavity.
作者信息
Piattelli Adriano, Rubini Corrado, Fioroni Massimiliano, Iezzi Giovanna, Santinelli Alfredo
机构信息
Oral Medicine and Pathology, Dental School, University of Chieti, Chieti, Italy.
出版信息
J Oral Maxillofac Surg. 2002 May;60(5):532-40. doi: 10.1053/joms.2002.31851.
PURPOSE
Loss of normal p53 is correlated to the progression of several preneoplastic lesions to neoplasms, and overexpression of bcl-2 determines an alteration of programmed cell death. There is an increased awareness of the importance of apoptosis in cancerogenesis, and a strong correlation of Ki-67 with high tumor grade has been reported.
MATERIALS AND METHODS
The aim of our study was to investigate immunohistochemically the expression and relationship of p53, bcl-2, MIB-1, and the apoptotic index (AI) in normal oral epithelium, leukoplakia, dysplasia, and oral squamous cell carcinoma.
RESULTS
A strong correlation was found between p53 overexpression and cell proliferation (MIB-1) and the AI. An inverse relationship was found between bcl-2 expression and MIB-1 and AI. A significant inverse relationship was found between p53 and bcl-2. A good positive correlation was present between AI and MIB-1 expression.
CONCLUSIONS
Apoptosis could be important to help to understand oral carcinogenesis.
目的
正常p53功能丧失与多种癌前病变发展为肿瘤相关，而bcl-2的过表达会导致程序性细胞死亡的改变。人们越来越意识到细胞凋亡在肿瘤发生中的重要性，并且有报道称Ki-67与高肿瘤分级密切相关。
材料与方法
本研究旨在通过免疫组织化学方法研究p53、bcl-2、MIB-1以及凋亡指数（AI）在正常口腔上皮、白斑、发育异常及口腔鳞状细胞癌中的表达及相互关系。
结果
发现p53过表达与细胞增殖（MIB-1）及AI之间存在强相关性。bcl-2表达与MIB-1及AI之间呈负相关。p53与bcl-2之间存在显著负相关。AI与MIB-1表达之间存在良好的正相关。
结论
细胞凋亡对于理解口腔癌发生可能具有重要意义。
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