口腔黏膜的良性增生性上皮病变很少与α、β或γ人乳头瘤病毒相关。
Benign proliferative epithelial lesions of oral mucosa are infrequently associated with α-, β-, or γ human papillomaviruses.
作者信息
Kerge Sirli, Vuorinen Jessi, Hurme Saija, Soukka Tero, Gheit Tarik, Tommasino Massimo, Syrjänen Stina, Rautava Jaana
机构信息
Department of Oral Diseases Turku University Hospital Turku Finland.
Department of Oral Pathology University of Turku Turku Finland.
出版信息
Laryngoscope Investig Otolaryngol. 2018 Dec 3;4(1):43-48. doi: 10.1002/lio2.222. eCollection 2019 Feb.
BACKGROUND
Oral papillomas and verruca vulgaris have been associated with human papillomavirus (HPV) infection. However, approximately half of these have remained HPV-negative when tested for mucosal HPV genotypes. In this study, we evaluated presence of α-, β-, and γ-HPVs in benign papillary and verrucous lesions.
METHODS
Eighty-three clinical lesions with suspected HPV etiology were analyzed for HPV types of genus α (n = 24), β (n = 46), and γ (n = 52). Immunohistochemistry was used for p16 as a possible surrogate marker of high-risk HPV, accompanied by Ki-67 proliferation marker.
RESULTS
Altogether, α-HPVs were detected in 6.4%, β-HPVs in 2.4%, and γ-HPV in 4.8%. The following genotypes were identified: HPV6, 8, 11, 16, 22, 161, and 170. Neither Ki-67 nor p16 positivity alone were associated with HPV but combined staining showed significant inverse association ( = .042).
CONCLUSION
HPV infection is found only in a minority of benign verrucous and papillary oral lesions, with the predominance of α-HPVs.
LEVEL OF EVIDENCE
背景
口腔乳头瘤和寻常疣与人乳头瘤病毒（HPV）感染有关。然而，在检测黏膜HPV基因型时，其中约一半仍为HPV阴性。在本研究中，我们评估了良性乳头状和疣状病变中α、β和γ-HPV的存在情况。
方法
对83例疑似HPV病因的临床病变进行分析，检测α属（n = 24）、β属（n = 46）和γ属（n = 52）的HPV类型。免疫组织化学检测p16作为高危HPV的可能替代标志物，并检测Ki-67增殖标志物。
结果
总共检测到6.4%的α-HPV、2.4%的β-HPV和4.8%的γ-HPV。鉴定出以下基因型：HPV6、8、11、16、22、161和170。单独的Ki-67或p16阳性均与HPV无关，但联合染色显示出显著的负相关（P = 0.042）。
结论
HPV感染仅在少数良性疣状和乳头状口腔病变中发现，以α-HPV为主。
证据水平
4级。
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