Raffa Demetrio, Daidone Giuseppe, Plescia Fabiana, Schillaci Domenico, Maggio Benedetta, Torta Livio
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Italy.
Farmaco. 2002 Mar;57(3):183-7. doi: 10.1016/s0014-827x(01)01190-9.
N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of the N-substitution with an aromatic heterocyclic system on benzamide moiety. Among the tested iododerivatives, compounds 6d,f,g,h possess interesting activities toward some phytopathogenic fungal strains.
为了研究苯甲酰胺部分上用芳族杂环系统进行N-取代对其抗真菌活性的作用，通过在乙酸中使相应的苯并三嗪酮5与碘化钾回流1小时，合成了具有类似苯菌灵结构的N-（1-苯基-4-羧基吡唑-5-基）-、N-（吲唑-3-基）-和N-（吲唑-5-基）-2-碘苯甲酰胺6。在所测试的碘衍生物中，化合物6d、f、g、h对一些植物病原真菌菌株具有有趣的活性。
