带有1-苯基-1H-吲唑核且具有镇痛和抗炎活性的乙酸类化合物。
Acetic acids bearing the 1-phenyl-1H-indazole nucleus with analgesic and antiinflammatory activity.
作者信息
Mosti L, Menozzi G, Schenone P, Molinario L, Conte F, Montanario C, Marmoe E
机构信息
Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
出版信息
Farmaco Sci. 1988 Oct;43(10):763-74.
PMID:3266483
Abstract
The synthesis of [(1-phenyl-1H-indazol-4-yl)oxy]acetic acid (IV), (1-phenyl-1H-indazol-4-yl)acetic acid (IX) and (1,5,6,7)tetrahydro-1-phenyl-4H-indazol-4-iminooxy)acetic acid (XIII) starting from 1,5,6,7-tetrahydro-1-phenyl-4H-indazol-4-one (I) is described. These compounds showed a good antiinflammatory activity in rats, and an analgesic activity in mice similar or comparable to that of indomethacin.
摘要
描述了从1,5,6,7-四氢-1-苯基-4H-吲唑-4-酮（I）开始合成[(1-苯基-1H-吲唑-4-基)氧基]乙酸（IV）、(1-苯基-1H-吲唑-4-基)乙酸（IX）和(1,5,6,7)四氢-1-苯基-4H-吲唑-4-亚氨基氧基)乙酸（XIII）的方法。这些化合物在大鼠中显示出良好的抗炎活性，在小鼠中的镇痛活性与吲哚美辛相似或相当。
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