Koh Gou Young, Kim Injune, Kwak Hee Jin, Yun Mi-Jeong, Leem Jae Chan
National Creative Research Initiatives Center for Endothelial Cells, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Republic of Korea.
Exp Mol Med. 2002 Mar 31;34(1):1-11. doi: 10.1038/emm.2002.1.
Until recently, vascular endothelial growth factor (VEGF) was the only growth factor proven to be specific and critical for blood vessel formation. Other long-known factors, such as the fibroblast growth factors (FGFs), platelet-derived growth factor, or transforming growth factor-beta, had profound effects in endothelial cells. But such factors were nonspecific, in that they could act on many other cells, and it seemed unlikely that these growth factors would be effective targets for treatment of endothelial cell diseases. A recently discovered endothelial cell specific growth factor, angiopoietin, has greatly contributed to our understanding of the development, physiology, and pathology of endothelial cells (Davis et al., 1996; Yancopoulos et al., 2000). The recent studies that identified and characterized the physiological and pathological roles of angiopoietin have allowed us to widen and deepen our knowledge about blood vessel formation and vascular endothelial function. Therefore, in this review, we describe the biomedical significance of these endothelial cell growth factors, the angiopoietins, in the vascular system under normal and pathological states.
直到最近，血管内皮生长因子（VEGF）仍是唯一被证明对血管形成具有特异性且至关重要的生长因子。其他早为人知的因子，如成纤维细胞生长因子（FGFs）、血小板衍生生长因子或转化生长因子-β，在内皮细胞中具有深远影响。但这些因子是非特异性的，因为它们可作用于许多其他细胞，而且这些生长因子似乎不太可能成为治疗内皮细胞疾病的有效靶点。最近发现的一种内皮细胞特异性生长因子——血管生成素，极大地促进了我们对内皮细胞发育、生理学和病理学的理解（戴维斯等人，1996年；扬科波洛斯等人，2000年）。最近鉴定并表征血管生成素生理和病理作用的研究，使我们能够拓宽和深化对血管形成和血管内皮功能的认识。因此，在本综述中，我们描述了这些内皮细胞生长因子——血管生成素在正常和病理状态下的血管系统中的生物医学意义。
