Laboratory of Animal Physiology and Medicine, Department of Biology Education, Korea National University of Education, Cheongju, Korea.
Physiol Rep. 2023 Nov;11(21). doi: 10.14814/phy2.15864.
Menopause is associated with vascular dysfunction attributed to reduced estrogen levels. Exercise has been proposed to promote angiogenesis and vascular dysfunction. However, studies of brain angiogenesis during menopause are limited. We analyzed the effects of exercise on angiogenesis-related factors in menopausal rat model. Twenty-week-old female Sprague-Dawley rats (N = 18) were randomly divided into a normal control group (N, n = 6), an ovariectomized control group (OVX, n = 6), and an ovariectomy + exercise group (OVX-EX, n = 6). Treadmill exercises were conducted in the OVX-EX group for 8 weeks (15-60 m/min, 1 h/day, and 5 days/week). The current study showed that the expression of angiogenesis-related factors (platelet-derived growth factor subunit A, B, vascular endothelial growth factor, angiopoietin 1, and angiopoietin 2) significantly decreased in the cortex of the OVX group. However, these factors were significantly restored in the cortex of the OVX-EX group after 8 weeks of treadmill exercise. In summary, estrogen deficiency causes vascular dysfunction by inhibiting the expression of angiogenesis-related factors. However, exercise can restore angiogenesis-related factors in OVX rats. Exercise eventually prevents vascular dysfunction in the brain and may help prevent cognitive dysfunction in menopausal women.
绝经与雌激素水平降低导致的血管功能障碍有关。运动被认为可以促进血管生成和血管功能障碍。然而，关于绝经期间大脑血管生成的研究有限。我们分析了运动对绝经大鼠模型中血管生成相关因子的影响。将 20 周龄的雌性 Sprague-Dawley 大鼠（N=18）随机分为正常对照组（N，n=6）、卵巢切除对照组（OVX，n=6）和卵巢切除+运动组（OVX-EX，n=6）。OVX-EX 组进行了 8 周的跑步机运动（15-60m/min，每天 1 小时，每周 5 天）。本研究显示，血管生成相关因子（血小板衍生生长因子亚单位 A、B、血管内皮生长因子、血管生成素 1 和血管生成素 2）在 OVX 组皮质中的表达明显下降。然而，经过 8 周的跑步机运动后，这些因子在 OVX-EX 组的皮质中得到了显著恢复。综上所述，雌激素缺乏通过抑制血管生成相关因子的表达导致血管功能障碍。然而，运动可以恢复 OVX 大鼠的血管生成相关因子。运动最终可以预防大脑中的血管功能障碍，并可能有助于预防绝经女性的认知功能障碍。
