Arendt R
Z Gesamte Inn Med. 1975 May 15;30(10):349-53.
In 36 patients with ulcer without Zollinger-Ellison-syndrome (25 patients with recurrent duodenal ulcer, 11 with an ulcus pepticum jejuni after B II-resection of the stomach) and 2 patients suffering from ulcus pepticum jejuni with an ascertained gastrinoma the secretion of acid was compared after stimulation of pentagstrin (6 mug/kg) and calcium (4 mg Ca++/kg/h). The secretion of hydrochloric acid was statistically significantly stimulated in all patients suffering from ulcer by the hypercalcaemia (increase of the serum calcium concentration from 5.0 +/- 0.3 mval/1 to 6.2 +/- 0.8 mval/1). But in patients suffering from ulcer with gastrinoma the stimulatory effect was larger than in such patients without autonomous source of gastrin: the calcium-stimulated secretion of hydrochloric acid was on the average in cases of duodenal ulcer 40% (2 to 68%), in the ulcera peptica jejuni 47% (17 to 75%), in the 4 comparative examinations of the two patients with Zollinger-Ellison-syndrome, however, always more than 100% (106 to 177%) of the pentagastrin-stimulated peak secretion. The comparative test of the pentagastrin and calcium-stimulated secretion of hydrochloric acid could be a help for the proof of autonomous places of the formation of gastrin.
对36例无佐林格-埃利森综合征的溃疡患者（25例复发性十二指肠溃疡患者，11例胃B II切除术后空肠溃疡患者）以及2例确诊为胃泌素瘤的空肠溃疡患者，在给予五肽胃泌素（6 μg/kg）和钙（4 mg Ca++/kg/h）刺激后，比较其胃酸分泌情况。高钙血症（血清钙浓度从5.0±0.3 mval/1升高至6.2±0.8 mval/1）使所有溃疡患者的盐酸分泌在统计学上有显著增加。但胃泌素瘤所致溃疡患者的刺激作用大于无胃泌素自主分泌源的患者：十二指肠溃疡患者钙刺激的盐酸分泌平均增加40%（2%至68%），空肠溃疡患者增加47%（17%至75%），然而，在对2例佐林格-埃利森综合征患者进行的4次对比检查中，钙刺激的盐酸分泌总是超过五肽胃泌素刺激的峰值分泌的100%（106%至177%）。五肽胃泌素和钙刺激的盐酸分泌对比试验可能有助于证实胃泌素形成的自主部位。
