Hotz J, Goebell H
Z Gastroenterol Verh. 1976(10):71-7.
Using a 12-hour infusion of salmon synthetic calcitonin (S-CT), distinct and sustained inhibition of gastric acid and pepsin secretion has been demonstrated in 4 normal subjects, 3 patients with peptic ulcer disease and 3 high risk patients. In 3 patients with Zollinger-Ellison syndrome, treated in the same way, elevated serum gastrin was reduced by about 50% and acid secretion by more than 90%. In healthy volunteers oral administration of human synthetic CT (H-CT) led to reduction in basal and pentagastrin-stimulated acid and pepsin secretion by about 50%, lasting for more than 2 hours after the instillation of CT. In 4 subjects receiving CT intravenously, slight nausea and headache were registered, while there were no side effects after the oral route. Serum calcium did not change after i.v. or oral administration of CT. Wheras therapeutical applications of CT, given by i.v. route, seem to be restricted to selected cases, i.e. acute gastric ulcerations with imminent or existent bleeding, the eventual benefit or orally administered CT in peptic ulcer disease should be evaluated in controlled long-term trials.
通过对4名正常受试者、3名消化性溃疡病患者和3名高危患者进行12小时的鲑鱼合成降钙素（S-CT）输注，已证实胃酸和胃蛋白酶分泌受到明显且持续的抑制。对3名佐林格-埃利森综合征患者采用同样的治疗方法，血清胃泌素水平升高约50%，胃酸分泌减少超过90%。在健康志愿者中，口服人合成降钙素（H-CT）可使基础胃酸分泌和五肽胃泌素刺激的胃酸及胃蛋白酶分泌减少约50%，在滴注降钙素后持续超过2小时。在4名静脉注射降钙素的受试者中，出现了轻微恶心和头痛，而口服给药后未出现副作用。静脉注射或口服降钙素后血清钙水平未发生变化。虽然静脉注射途径给予降钙素的治疗应用似乎仅限于特定病例，即有即将发生或已存在出血的急性胃溃疡，但口服降钙素在消化性溃疡病中的最终益处应在长期对照试验中进行评估。
