Stragier Ilse, Snoeck Robert, De Clercq Erik, Van Den Oord Joost J, Van Ranst Marc, De Greef Hugo
Department of Dermatology, U.Z. Leuven, Leuven, Belgium.
J Med Virol. 2002 Jun;67(2):241-5. doi: 10.1002/jmv.2213.
Human papillomavirus (HPV) induced epithelial cell proliferation is responsible for a broad range of lesions. Treatment of such lesions is characterized by a high relapse rate. Four patients are described who were treated locally with cidofovir (cream 1% or injection of 2.5 mg/ml solution) for multi-treated relapsing HPV-associated lesions. Three of the four patients had a complete response. The fourth patient showed a clinical response in the first cycle of treatment, but new lesions appeared during four successive cycles of cidofovir.
人乳头瘤病毒（HPV）诱导的上皮细胞增殖会引发多种病变。此类病变的治疗特点是复发率高。本文描述了4例因多次治疗后复发的HPV相关病变而局部使用西多福韦（1%乳膏或2.5mg/ml溶液注射）治疗的患者。4例患者中有3例完全缓解。第4例患者在治疗的第一个周期有临床反应，但在随后连续4个西多福韦治疗周期中出现了新的病变。
