Calista D
M. Bufalini Hospital, Dermatology unit, Cesena, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Dec;90(6):713-5. doi: 10.1067/moe.2000.110413.
Cidofovir, a purine nucleotide analogue of cytosine, is a promising new drug that acts against a wide number of DNA viruses. In 1997, the Food and Drug Administration approved intravenous cidofovir for the treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Recent studies have shown cidofovir (1% gel or cream) to be effective for the treatment of recalcitrant and unmanageable viral cutaneous lesions induced by herpes, pox, and papillomavirus families. We report the case of a 45-year-old man who had been diagnosed as having acquired immunodeficiency syndrome in 1995. Recalcitrant to conventional therapies, the human papillomavirus lesions on his gingival mucosa were successfully treated with cidofovir 1% cream. To the best of our knowledge, this is the first case in which topical cidofovir has been used for the treatment of a human papillomavirus infection of the oral mucosa.
西多福韦是胞嘧啶的嘌呤核苷酸类似物，是一种有前景的新型药物，可对抗多种DNA病毒。1997年，美国食品药品监督管理局批准静脉注射西多福韦用于治疗获得性免疫缺陷综合征患者的巨细胞病毒性视网膜炎。最近的研究表明，西多福韦（1%凝胶或乳膏）对治疗由疱疹、痘病毒和乳头瘤病毒家族引起的顽固性和难以处理的病毒性皮肤损伤有效。我们报告一例45岁男性病例，该患者于1995年被诊断为获得性免疫缺陷综合征。其牙龈黏膜上的人乳头瘤病毒损伤对传统治疗耐药，使用1%西多福韦乳膏成功治愈。据我们所知，这是首例局部使用西多福韦治疗口腔黏膜人乳头瘤病毒感染的病例。
