Ikeya Kazumori, Kume Masaki, Sato Hiroaki, Kashimoto Satoshi, Kumazawa Teruo
Department of Anesthesia, Kofu Municipal Hospital, Kofu 400-0832.
Masui. 2002 Apr;51(4):377-81.
We evaluated the effects of prostaglandin E1 (PGE1) on the liver function and hemorrhage after total hip arthroplasty (THA). Twenty patients with normal liver function were randomly divided into two groups. The patients were anesthetized with spinal anesthesia using 0.5% bupivacaine 4 ml and epidural anesthesia. The laryngeal mask was inserted after administrations of 1.5-2 mg.kg-1 of propofol and 0.8 mg.kg-1 of succinylcholine. PGE1 was infused in the PGE1 group at a rate of 0.01 microgram.kg-1.min-1 (PGE1 group) during and after the operation (30-40 hrs). GOT and GPT values were evaluated before, and at the end of operation, and on 1, 4 and 7 postoperative days in each group. The amount of hemorrhage was measured at the end of operation and on 1, 2, 3 and 4 postoperative days in each group. GOT values on 1 and 4 postoperative days in PGE1 group were significantly lower than those in the control group. GPT values on 1, 4 and 7 postoperative days in PGE1 group were also significantly lower than those in the control group. The amount of bleeding during the operation and postoperative hemorrhage did not differ significantly between the two groups. These results suggest that PGE1 may prevent postoperative liver damage, but it may not affect the amount of postoperative bleeding.
我们评估了前列腺素E1（PGE1）对全髋关节置换术（THA）后肝功能及出血情况的影响。20例肝功能正常的患者被随机分为两组。患者采用0.5%布比卡因4毫升行脊髓麻醉及硬膜外麻醉。给予1.5 - 2毫克/千克丙泊酚和0.8毫克/千克琥珀酰胆碱后插入喉罩。PGE1组在手术期间及术后（30 - 40小时）以0.01微克/千克·分钟 - 1的速率输注PGE1。每组分别在手术前、手术结束时、术后第1天、第4天和第7天评估谷草转氨酶（GOT）和谷丙转氨酶（GPT）值。每组分别在手术结束时、术后第1天、第2天、第3天和第4天测量出血量。PGE1组术后第1天和第4天的GOT值显著低于对照组。PGE1组术后第1天、第4天和第7天的GPT值也显著低于对照组。两组手术期间出血量及术后出血情况差异无统计学意义。这些结果表明，PGE1可能预防术后肝损伤，但可能不影响术后出血量。
