Schwartz R B, Kacher D F, Pergolizzi R S, Jolesz F A
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Neuroimaging Clin N Am. 2001 Nov;11(4):629-44.
Intraoperative MR imaging provides an unrestricted view of intracranial structures and lesions that has revolutionized the way that neurosurgery is performed in the authors' institution. Intraoperative imaging allows the practitioner to update and adjust the approach to intracranial lesions continuously. With this system, important anatomic and vascular structures can be successfully avoided; boundaries of low-grade tumors can be accurately defined, and foci of possible higher grade within these lesions can be identified; foci of high-grade astrocytomas can be differentiated from radiated brain; hyperacute hemorrhage or infarction during and after procedures can be determined; and the possible communication of cystic collections with CSF can be ascertained. These advantages provide a level of comfort to the surgeon and a presumptive margin of safety to the patient that is unattainable during conventional surgical approaches, and given the choice, the authors' neurosurgeons would prefer to operate in the interventional magnet. Preliminary reports concerning the efficacy and usefulness of MR-guided navigational tools for the performance of neurosurgery are encouraging, as noted earlier, Wirtz et al have shown that the more extensive removal of glioblastomas afforded by intraoperative MR leads to significantly prolonged patient survival compared with conventional surgery. Further outcomes analysis must be performed, however, to determine whether these new techniques significantly decrease overall long-term morbidity or increase survival in those patients who have low-grade astrocytomas.
术中磁共振成像能够提供对颅内结构和病变的无限制视野,这彻底改变了作者所在机构进行神经外科手术的方式。术中成像使术者能够持续更新和调整针对颅内病变的手术入路。借助该系统,重要的解剖和血管结构能够成功避开;低级别肿瘤的边界能够精确界定,并且能够识别这些病变内可能存在的更高级别病灶;高级别星形细胞瘤的病灶能够与放射性脑区分开来;能够确定手术期间及术后的超急性出血或梗死情况;还能够确定囊性积液与脑脊液之间可能存在的连通情况。这些优势为外科医生提供了一定程度的安心,为患者提供了传统手术方法无法实现的假定安全边际。如果可以选择,作者所在机构的神经外科医生更倾向于在介入磁体中进行手术。如前文所述,关于磁共振引导导航工具在神经外科手术中应用的疗效和实用性的初步报告令人鼓舞,维尔茨等人已经表明,与传统手术相比,术中磁共振成像使胶质母细胞瘤的切除范围更广,从而显著延长了患者的生存期。然而,必须进行进一步的结果分析,以确定这些新技术是否能显著降低总体长期发病率,或提高低级别星形细胞瘤患者的生存率。